Epigenetics of environmental exposures

July 29, 2016

We are exploring the environmental influences on the germline epigenome and their effects over multiple generations. We are taking advantage of various innovative models and genetic tools to detect chemical disruption of the germline chromatin and in particular of evolutionary conserved epigenetic marks such as histone modifications. Through the collection of assays developed in the Allard lab, we can investigate the multi- and trans-generational transmission of altered chromatin states originating from a single generational exposure. With this research, we not only identify the chemicals that affect the epigenome but also characterize their mechanism of action on epigenetic pathways.

 

 

 

 

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© 2019 by Patrick Allard