SELECTED PUBLICATION (for full publication list, please click on the google scholar link above)

2019

Chen Y, Panter B, Hussein A, Gibbs K, Ferreira D, Allard P. BPA interferes with StAR-mediated mitochondrial cholesterol transport to induce germline dysfunctions. Reprod Toxicol. 2019 Aug 21;90:24-32. doi: 10.1016/j.reprotox.2019.08.001.

Frésard L, Smail C, Ferraro NM, Teran NA, Li X, Smith KS, Bonner D, Kernohan KD, Marwaha S, Zappala Z, Balliu B, Davis JR, Liu B, Prybol CJ, Kohler JN, Zastrow DB, Reuter CM, Fisk DG, Grove ME, Davidson JM, Hartley T, Joshi R, Strober BJ, Utiramerur S; Undiagnosed Diseases Network; Care4Rare Canada Consortium, Lind L, Ingelsson E, Battle A, Bejerano G, Bernstein JA, Ashley EA, Boycott KM, Merker JD, Wheeler MT, Montgomery SB. Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts. Nat Med. 2019 Jun;25(6):911-919. doi: 10.1038/s41591-019-0457-8. Epub 2019 Jun 3.

Silverman EK, Allard P, Loscalzo J, Mulvihill JJ, Korrick SA. Undiagnosed Diseases Network.Reported environmental exposures are inversely associated with obtaining a genetic diagnosis in the Undiagnosed Diseases Network. Am J Med Genet A. 2019 Jun;179(6):958-965. doi: 10.1002/ajmg.a.61132. Epub 2019 Mar 23.

Shu L, Meng Q, Diamante G, Tsai B, Chen YW, Mikhail A, Luk H, Ritz B, Allard P, Yang X. Prenatal Bisphenol A Exposure in Mice Induces Multi-tissue Multi-omics Disruptions Linking to Cardiometabolic Disorders. Endocrinology. 2019 Feb 1;160(2):409-429. doi: 10.1210/en.2018-00817.

2018

Camacho J, Allard P. Histone Modifications: Epigenetic Mediators of Environmental Exposure Memory. Epigenet Insights. 2018 Oct 14;11:2516865718803641. doi: 10.1177/2516865718803641. eCollection 2018. PMID: 30443644

Splinter K, Adams DR, Bacino CA, Bellen HJ, Bernstein JA, Cheatle-Jarvela AM, Eng CM, Esteves C, Gahl WA, Hamid R, Jacob HJ, Kikani B, Koeller DM, Kohane IS, Lee BH, Loscalzo J, Luo X, McCray AT, Metz TO, Mulvihill JJ, Nelson SF, Palmer CGS, Phillips JA 3rd, Pick L, Postlethwait JH, Reuter C, Shashi V, Sweetser DA, Tifft CJ, Walley NM, Wangler MF, Westerfield M, Wheeler MT, Wise AL, Worthey EA, Yamamoto S, Ashley EA; Undiagnosed Diseases Network. Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease. N Engl J Med. 2018 Nov 29;379(22):2131-2139. doi: 10.1056/NEJMoa1714458. Epub 2018 Oct 10.

Camacho J, Truong L, Kurt Z, Chen YW, Morselli M, Gutierrez G, Pellegrini M, Yang X, Allard P. The Memory of Environmental Chemical Exposure in C. elegans Is Dependent on the Jumonji Demethylases jmjd-2 and jmjd-3/utx-1. Cell Reports, Volume 23, Issue 8, 2392 - 2404

 

Angrish MM, Allard P, McCullough SD, Druwe IL, Helbling Chadwick L, Hines E, Chorley BN. Epigenetic Applications in Adverse Outcome Pathways and Environmental Risk Evaluation. Environ Health Perspect. 2018 Apr 12;126(4):045001. doi: 10.1289/EHP2322.

 

Oláhová M, Yoon WH, Thompson K, Jangam S, Fernandez L, Davidson JM, Kyle JE, Grove ME, Fisk DG, Kohler JN, Holmes M, Dries AM, Huang Y, Zhao C, Contrepois K, Zappala Z, Frésard L, Waggott D, Zink EM, Kim YM, Heyman HM, Stratton KG, Webb-Robertson BM; Undiagnosed Diseases Network, Snyder M, Merker JD, Montgomery SB, Fisher PG, Feichtinger RG, Mayr JA, Hall J, Barbosa IA, Simpson MA, Deshpande C, Waters KM, Koeller DM, Metz TO, Morris AA, Schelley S, Cowan T, Friederich MW, McFarland R, Van Hove JLK, Enns GM, Yamamoto S, Ashley EA, Wangler MF, Taylor RW, Bellen HJ, Bernstein JA, Wheeler MT.  Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder. Am J Hum Genet. 2018 Mar 1;102(3):494-504. doi: 10.1016/j.ajhg.2018.01.020. Epub 2018 Feb 22.

 

2017

HF Chen, CE Wu, CW Yu, KW Chang, WH Chou, CY Lu, E Ghelfi, FC Wu, PS Jan, MC Huang, P Allard, SP Lin, HN Ho. Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation. Exp Mol Med. 2017 Sep 15;49(9):e376.

 

Zaunbrecher V, Beryt E, Parodi D, Telesca D, Doherty J, Malloy T, Allard P. Has Toxicity Testing moved into the 21st Century? A Survey and Analysis of Perceptions in the Field of Toxicology. Environmental Health Perspectives. DOI:10.1289/EHP1435

 

J Wang, R Al-Ouran, Y Hu, SY Kim, YW Wan, MF Wangler, S Yamamoto, et. MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome. The American Journal of Human Genetics 100 (6), 843-853. 2017.

 

T Malloy, V Zaunbrecher, E Beryt, R Judson, R Tice, P Allard, A Blake, et al.  Advancing alternatives analysis: The role of predictive toxicology in selecting safer chemical products and processes. Integrated Environmental Assessment and Management. 2017.

 

RB Ramoni, JJ Mulvihill, DR Adams, P Allard, EA Ashley, JA Bernstein, et al. The Undiagnosed Diseases Network: Accelerating Discovery about Health and Disease.The American Journal of Human Genetics 100 (2), 185-192. 2017.

 

K Schoch, L Meng, S Szelinger, DR Bearden, A Stray-Pedersen, OL Busk, et al. A Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay. The American Journal of Human Genetics 100 (2), 343-351. 2017.

 

HT Chao, M Davids, E Burke, JG Pappas, JA Rosenfeld, AJ McCarty, et al. A syndromic neurodevelopmental disorder caused by de novo variants in EBF3. The American Journal of Human Genetics 100 (1), 128-137. 2017.

 

DB Zastrow, PA Zornio, A Dries, J Kohler, L Fernandez, D Waggott, et al. Exome sequencing identifies de novo pathogenic variants in FBN1 and TRPS1 in a patient with a complex connective tissue phenotype. Molecular Case Studies 3 (1), a001388. 2017.

 

2016

V Shashi, LDM Pena, K Kim, B Burton, M Hempel, K Schoch, et al. De novo truncating variants in ASXL2 are associated with a unique and recognizable clinical phenotype. The American Journal of Human Genetics 99 (4), 991-999.  2016.

 

Yichang Chen, Le Shu, Zhiqun Qiu, Dong Yeon Lee, Sara J Settle, Shane Que Hee, Donatello Telesca, Xia Yang, Patrick AllardExposure to the BPA-Substitute Bisphenol S Causes Unique Alterations of Germline Function. PLOS Genetics 12 (7), e1006223. 2016.

 

A Bashamboo, PA Donohoue, E Vilain, S Rojo, P Calvel, SN Seneviratne, et al. A recurrent p. Arg92Trp variant in steroidogenic factor-1 (NR5A1) can act as a molecular switch in human sex development. Human molecular genetics 25 (16), 3446-3453.  2016

 

Lundby Z, Camacho J, Allard P. Fast functional germline and epigenetic assays in the nematode Caenorhabditis elegans. In High Throughput Toxicity Assays: Methods and Protocols. Springer 2016. Chapter.

 

2015

Allard P. “Emerging Toxicity Models from Emerging Scientists” Toxicology research. 4(3):545-547. Perspective article. * Featured in “New Talents” issue.

 

Parodi DA, Chen Y, Sarif J, Allard P. “Reproductive toxicity and meiotic dysfunction following exposure to the pesticides Maneb, Diazinon and Fenarimol”. Toxicology Research. 4(3):645-654. * Featured in “New Talents” issue.  2015.

 

Ferreira D, Allard P. “Models of germ cell development and their application for toxicity studies”. Environmental and Molecular Mutagenesis. PMID: 25821157. Review. 2015.

 

Parodi DA, Damoiseaux R, Allard P. “Comprehensive assessment of germline chemical toxicity using the nematode 1 Caenorhabditis elegans”. J. Vis. Exp. (96), e52445, doi:10.3791/52445. 2015.

 

2014

Ferreira D, Chen Y, Allard P. “Use of the alternative model system C. elegans in developmental and Reproductive Toxicology”. In Developmental & Reproductive Toxicology (ed. Dr Ali Faqi). Springer. Chapter. 2014.

 

2013

Allard P. Biomarkers of Bisphenol A Toxicity. In Biomarkers in Toxicology (ed. Dr Ramesh Gupta). Elsevier Inc. Chapter. 2013.

 

Allard P, Kleinstreuer N, Knudsen T, Colaiacovo MP. A screening platform for the rapid assessment of chemical disruption of germline function. Environmental Health Perspectives. Jun;121(6):717-24. 2013.

 

2011

Allard P, Colaiacovo MP. Mechanistic insights into the action of Bisphenol A on the germline using C. elegans. Cell Cycle. Jan 15;10(2):183-4. Review. 2011.

 

Allard P, Colaiacovo MP. Bisphenol A: metabolism, mechanisms and toxicity. In Reproductive and Developmental Toxicology (ed. Ramesh C. Gupta). Elsevier Inc. Chapter. 2011.

 

2010

Allard P, Colaiacovo MP. Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities. Proc Natl Acad Sci U S A. Nov 23; 107(47): 20405-10010. *Featured in JAMA. 2011;305(1):28.

 

Yang Q*, Allard P*, Huang M, Zheng W, Clarke HJ. Proteasomal activity is required to initiate and to sustain translational activation of messenger RNA encoding the Stem-Loop-Binding Protein during meiotic maturation in mice. Biology of Reproduction. Jan;82(1):123-31. 2010.

 

2009

Allard P, Tabin CJ. Achieving bilateral symmetry during vertebrate limb development. Seminars in Cell & Developmental Biology. Jun;20(4):479-84. Review. 2009.

 

2007

Nissim S, Allard P, Bandyopadhyay A, Harfe BD, Tabin CJ. Characterization of a novel ectodermal signaling center regulating Tbx2 and Shh in the vertebrate limb. Developmental Biology. Apr 1;304(1):9-21. 2007.

 

2006

Villaescusa JC, Allard P, Carminati E, Kontogiannea M, Talarico D, Blasi F, Farookhi R, Verrotti AC. Clast4, the murine homologue of human 4E-T, is expressed and post-translationally regulated during follicular development. Gene. Feb 15; 367:101-9. 2006.

 

2005

Allard P, Young Q, Marzluff WF, Clarke HJ. Stem-Loop Binding Protein accumulation during meiotic maturation is required for normal histone synthesis and embryonic chromatin assembly. Developmental Biology. Oct 1;286(1):195-206. 2005.

 

2002

Allard P*, Champigny MJ*, Skoggard S*, Erkmann JA, Whitfield ML, Marzluff WF, Clarke HJ. Stem-loop binding protein accumulates during oocyte maturation and is not cell-cycle-regulated in the early mouse embryo. Journal of Cell Science. Dec 1; 4577-86. 2002.

© 2019 by Patrick Allard